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Johnson & Johnson ($JNJ) announced receiving the approval from the regulatory authorities in the EU for its planned $30 billion takeover of Actelion. The approval has come through after the company pledged to spin-off one of the combined firm's two insomnia pipeline programs. Actelion's insomnia project will be transferred to a new company called Idorsia.  Johnson & Johnson will not be allowed to nominate a board member to the new entity. It will also limit its stake to 10% if it is the largest shareholder.
Johnson & Johnson stock has gained over 14 percent this year so far while its 12 months gain stands at 12 percent.

Lexicon Pharmaceuticals Inc. ($LXRX) announced that its Phase 3 clinical trail, TANDEM 3 met its primary endpoint of demonstrating superiority over placebo as measured by the proportion of patients achieving HbA1C levels less than 7.0% at week 24.  The study is designed to assess the efficacy of sotagliflozin for the treatment of type 1 diabetes. The results showed that  there were no episodes of hypoglycemia or diabetic ketoacidosis after randomization. The company has an agreement with Sanofi, which gives the company  global rights to the product, except for in Japan.
Lexicon stock is up 18 percent this year so far while its 12 years gain stands at 12 percent.

 

XBiotech ($XBIT) announced ending its Phase 3 clinical trial, XCITE, designed for  assessing lead product candidate Xilonix for the treatment of colorectal cancer. The decision has been taken pursuant to a second planned analysis by the Independent Data Monitoring Committee which determined that it would be unlikely to show sufficient efficacy to continue.
Tesaro ($TSRO) announced that it has suspended the patient recruitment in a Phase 2 clinical trial assessing niraparib for the treatment of prostate cancer being conducted by collaboration partner Janssen Biotech.  The FDA approved niraparib in March for treating certain patients with epithelial, ovarian, fallopian tube or primary peritoneal cancer.

Teva Pharmaceuticals Industries ($TEVA) announced the commercial launch of the generic versionof Novartis’ Pataday. Olopatadine hydrochloride ophthalmic solution 0.2% is a mast cell stabilizer indicated for treating ocular itching associated with allergic conjunctivitis.

 

Pfizer ($PFE) announced amending the protocol for the Phase 3 PROSPER clinical trial assessing XTANDI (enzalutamide) for the treatment of non-metastatic castration-resistant prostate cancer. The company is collaborating with Astellas Pharma for the study. XTANDI is currently approved in the U.S. to treat men with metastatic CRPC.
EyeGate Pharmaceuticals ($EYEG) announced the pricing of of a public offering of 6.7 million shares of common stock and warrants at an exercise price of $1.50 per share yielding gross proceeds of $10 million. Each share sold will have an accompanying five-year warrant to purchase one common share at $1.50.

Brokerage
Action
Company
Rating
Price Target
Impact on Share Price
Aegis
Initiates
ABAXIS (ABAX)
Hold
$56.50
High
Royal Bank of Canada
Raises Target
Aetna (AET)
Outperform
$147.00 -> $162.00
Low
Mizuho
Lowers Target
Allergan PLC. (AGN)
Buy -> Buy
$275.00 -> $267.00
Medium
Needham & Company LLC
Reiterates
Alder BioPharmaceuticals (ALDR)
Buy
$36.00
Low
Goldman Sachs Group, Inc. (The)
Reiterates
Alexion Pharmaceuticals (ALXN)
Buy
$142.00
Low
Citigroup
Reiterates
Anthera Pharmaceuticals (ANTH)
Neutral
$3.20 -> $2.00
Medium
Jefferies Group LLC
Reiterates
Axovant Sciences (AXON)
Buy
$31.00
Low
Cowen and Company
Reiterates
bluebird bio (BLUE)
Outperform

Low
Royal Bank of Canada
Reiterates
Boston Scientific Corporation (BSX)
Ourperform
$31.00 -> $29.00
Low

Gainers (% price change)Last TradeChangeMkt CapEnzo Biochem, Inc.ENZ10.38+1.20 (13.07%)486.89MLexicon PharmaceuticalsLXRX16.40+1.04 (6.77%)1.74BAntares Pharma IncATRS2.83+0.17 (6.39%)441.27MACADIA PharmaceuticalsACAD27.40+1.26 (4.82%)3.43BAcorda Therapeutics IncACOR16.90+0.70 (4.32%)837.67MLosers (% price change)Nova MeasuringNVMI25.28-1.99 (-7.30%)671.32MOclaro, Inc.OCLR9.63-0.74 (-7.14%)1.61BImmunoGen, Inc.IMGN4.39-0.26 (-5.59%)402.63MValeant PharmaceuticalsVRX12.52-0.74 (-5.58%)4.67BCirrus Logic, Inc.CRUS67.30-3.86 (-5.42%)4.39BMost Actives (dollar volume)Pfizer Inc.PFE32.77+1.02 (3.21%)193.62BJohnson & JohnsonJNJ131.53+0.98 (0.75%)353.78BMerck & Co., Inc.MRK64.39+1.19 (1.88%)173.75BAmgen, Inc.AMGN164.06+1.41 (0.87%)121.39BGilead Sciences, Inc.GILD64.70+0.58 (0.90%)84.28B